Dump and Bake Chicken Tzatziki Casserole

This dump and bake chicken tzatziki casserole is my go-to recipe when I want all those bright Mediterranean flavors without spending hours in the kitchen. Just toss everything into a baking dish and let the oven do the work while you relax or catch up on other things.

I discovered this recipe on one of those hectic weeknights when I had chicken to use up and a jar of tzatziki in the fridge. Instead of the usual baked chicken routine, I decided to mix things up with those tangy, creamy flavors I love from Greek restaurants. The result was this incredibly easy dump and bake chicken tzatziki casserole that my whole family devoured. Now it’s become my secret weapon for busy nights when I still want something special. The combination of tender chicken, cool cucumber, salty feta, and that signature tzatziki sauce creates a comforting meal that tastes like you spent way more time on it than you actually did.

What You’ll Need for This Mediterranean Chicken Bake

Before you start, gather your ingredients so everything goes smoothly. I always recommend using good quality tzatziki sauce since it’s the star of this dump and bake chicken tzatziki casserole. You can use store-bought or homemade, whichever you prefer.

• 2 pounds boneless, skinless chicken breasts, cut into 1-inch pieces
• 1 cup tzatziki sauce (I prefer full-fat for richer flavor)
• 1/2 cup plain Greek yogurt
• 1/2 cup crumbled feta cheese
• 1/2 cup chopped cucumber (English cucumbers work best)
• 1/4 cup chopped red onion
• 2 cloves garlic, minced
• 1 tablespoon fresh dill, chopped (dried dill works in a pinch, use 1 teaspoon)
• 1 tablespoon fresh lemon juice
• 1 teaspoon dried oregano
• 1/2 teaspoon salt
• 1/4 teaspoon black pepper
• 1 cup shredded mozzarella cheese

Pro tip: For the best texture and flavor, I recommend cutting your chicken into uniform 1-inch pieces so everything cooks evenly. If you’re short on time, you can use rotisserie chicken and just reduce the baking time.

How I Make This Easy Chicken Casserole

I recommend mixing everything thoroughly so each piece of chicken gets coated with that delicious tzatziki mixture. This ensures every bite is packed with flavor.

Step 1: Preheat your oven to 375°F (190°C). While it’s heating, grab your 9×13 inch baking dish and set it aside.

Step 2: In a large mixing bowl, combine the chicken pieces with the tzatziki sauce, Greek yogurt, feta cheese, cucumber, red onion, minced garlic, fresh dill, lemon juice, oregano, salt, and black pepper. Mix everything together until the chicken is completely coated. The mixture should look creamy and smell incredibly fresh.

Step 3: Transfer the chicken mixture to your prepared baking dish. Use a spatula to spread it out evenly across the dish. This helps everything cook at the same rate.

Step 4: Sprinkle the shredded mozzarella cheese evenly over the top. Don’t skip this step because the melted cheese creates a beautiful golden layer that locks in all the moisture.

Step 5: Bake uncovered for 30-35 minutes. You’ll know it’s done when the chicken reaches an internal temperature of 165°F and the cheese on top is melted, bubbly, and starting to turn golden in spots. If you like a crispier top, switch your oven to broil for the last 2-3 minutes while the dish is still in the oven, but watch it carefully to prevent burning.

Step 6: Let the casserole rest for 5 minutes before serving. This allows the juices to redistribute and makes it easier to serve.

Perfect Pairings for Your Chicken Tzatziki Bake

This dump and bake chicken tzatziki casserole pairs beautifully with sides that complement its Mediterranean profile.

Fluffy Rice Pilaf: The mild, buttery flavor of rice pilaf soaks up all that creamy tzatziki sauce perfectly, making each bite satisfying and complete.

Warm Pita Bread: Nothing beats using soft, warm pita to scoop up the chicken and sauce. It adds a wonderful texture contrast and makes the meal feel more authentic.

Greek Salad: A crisp salad with tomatoes, cucumbers, olives, and a light lemon vinaigrette balances the richness of the casserole while keeping the Mediterranean theme going.

Roasted Vegetables: Try roasted zucchini, bell peppers, or eggplant seasoned with olive oil and herbs. They add extra nutrition and their caramelized edges pair nicely with the creamy chicken.

Garlic Green Beans: Simple sautéed green beans with garlic bring a fresh, crisp element that cuts through the richness while adding vibrant color to your plate.

These are some of the best sides for chicken tzatziki casserole that I serve regularly.

More Mediterranean and Comfort Food Favorites

This dump and bake chicken tzatziki casserole fits beautifully into a Mediterranean-inspired menu alongside other flavorful dishes. For another Greek-influenced comfort meal, the Creamy Tuscan Garlic Tortellini Soup brings similar rich, herby flavors in soup form that work perfectly for cooler evenings.

When looking for easy protein-packed dinners with bold flavors, consider the Crispy Parmesan Chicken with Rich Garlic Sauce or the Best Parmesan Crusted Chicken with Creamy Garlic Sauce. Both feature that same satisfying combination of tender chicken with creamy, cheese-forward sauces. For a dump-and-bake style meal similar to this tzatziki casserole, try the Dump and Bake Chicken Alfredo Rice Casserole which offers the same hands-off convenience with Italian flavors.

Storing and Reheating Your Casserole

This dump and bake chicken tzatziki casserole stores beautifully, making it perfect for meal prep or enjoying leftovers throughout the week.

Let the casserole cool completely before transferring it to an airtight container. Store it in the refrigerator for up to 4 days. For longer storage, portion it into freezer-safe containers and freeze for up to 3 months. I recommend freezing individual portions so you can thaw only what you need.

To reheat, microwave individual portions for 2-3 minutes until warmed through, or reheat in a 350°F oven for about 15-20 minutes if reheating the whole dish. Add a splash of water or extra tzatziki if it seems dry. Frozen portions should be thawed overnight in the refrigerator before reheating for best results.

Pro tip: I like to make a double batch of this chicken tzatziki bake and freeze half for those nights when I really don’t feel like cooking. It’s like having a homemade frozen dinner that actually tastes amazing.

Common Questions About This Recipe

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